2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2396
    N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide
    N-​(3-​Methoxybenzyl-​(9z,​12z)​-​octadecadienamide (Macamide impurity 10) is the impurity of Macamide.
    N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide
  • HY-142592S
    Clozapine EP impurity D-d8
    Clozapine EP impurity D-d8 is the deuterium labeled Clozapine EP impurity D.
    Clozapine EP impurity D-d<sub>8</sub>
  • HY-117580S
    16α-Hydroxyprednisolone-d3
    16α-Hydroxyprednisolone-d3 is the deuterium labeled 16α-Hydroxyprednisolone. 16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily.
    16α-Hydroxyprednisolone-d<sub>3</sub>
  • HY-N0894A
    (3R,5R)-Octahydrocurcumin
    (3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2.
    (3R,5R)-Octahydrocurcumin
  • HY-113519
    14R(15S)-EET
    14R(15S)-EET (14R(15S)-EpETrE) is an oxylipin and a metabolite of Arachidonic acid (HY-109590).
    14R(15S)-EET
  • HY-143941S
    Hydroxychloroquine EP impurity D-d5 dihydrochloride
    Hydroxychloroquine EP impurity D-d5 (dihydrochloride) is the deuterium labeled Hydroxychloroquine EP impurity D dihydrochloride.
    Hydroxychloroquine EP impurity D-d<sub>5</sub> dihydrochloride
  • HY-114750
    Mebendazole-amine
    		98.35%
    Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine
  • HY-136124
    Cetilistat impurity 1
    Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat impurity 1
  • HY-115420
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E)) is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides.
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
  • HY-W777322
    3,4-Dihydroxybenzeneacetic acid-13C,18O2
    3,4-Dihydroxybenzeneacetic acid-13C,18O2 is the 13C- and 18O-labeled labeled 3,4-Dihydroxybenzeneacetic acid (HY-W001080). 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid-<sup>13</sup>C,<sup>18</sup>O<sub>2</sub>
  • HY-W727031
    2-Methylamino-1-phenylbutane hydrochloride
    2-Methylamino-1-phenylbutane hydrochloride is a metabolite of stimulant agents in blood.
    2-Methylamino-1-phenylbutane hydrochloride
  • HY-113879
    18-Carboxy dinor Leukotriene B4
    18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.
    18-Carboxy dinor Leukotriene B4
  • HY-137532
    7-Hydroxyquetiapine
    7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].
    7-Hydroxyquetiapine
  • HY-124030
    3-Hydroxyphenazepam
    3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [3H]GABA uptake.
    3-Hydroxyphenazepam
  • HY-W002112R
    (±)-Nornicotine (Standard)
    (±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine (HY-W002112). This product is intended for research and analytical applications. (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine (Standard)
  • HY-131253
    Febuxostat isopropyl isomer
    Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat isopropyl isomer
  • HY-103252R
    Monomethyl fumarate (Standard)
    Monomethyl fumarate (Standard) is the analytical standard of Monomethyl fumarate. This product is intended for research and analytical applications. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
    Monomethyl fumarate (Standard)
  • HY-W145498
    D-(+)-Cellotetraose
    D-(+)-Cellotetraose (Cellotetraose) is a primary hydrolysis product of cellulose.
    D-(+)-Cellotetraose
  • HY-B1342A
    13-cis-Vitamin A
    13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter.
    13-cis-Vitamin A
  • HY-P3006
    Des-Leu10-angiotensin I
    Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell.
    Des-Leu10-angiotensin I
Cat. No. Product Name / Synonyms Application Reactivity